To report the efficacy and safety of interferon ifn. Pegasys, peginterferon alfa 2a, is a covalent conjugate of recombinant alfa 2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Decrease or loss of vision, retinopathy including macular edema, retinal artery or vein thrombosis, retinal hemorrhage and cotton wool spots, optic neuritis. To evaluate the safety and efficacy of interferon alfa2a for the treatment of choroidal neovascularization secondary to agerelated macular degeneration. Interferon alfa 2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Symptoms began 19 weeks after starting peginterferon alpha2a.
We identified 23 additional cases of naion during interferon alpha therapy. Pdf clinical experience of interferon alfa2a treatment for. Purpose to evaluate the efficacy of interferon ifn alfa2a for the treatment of long lasting refractory cystoid macular edema cme in noninfectious uveitis. The wet form of agerelated macular degeneration amd affects approximately 250,000 americans per year. Request pdf successful treatment of chronic pseudophakic macular edema irvine gass syndrome with interferon alpha. Interferon alfa2b should be used cautiously in patients with debilitating conditions such as those with a history of cardiac disease e. Agerelated macular degeneration amd is one of the significant. Peginterferon alfa 2a, is a covalent conjugate of recombinant alfa 2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain approximate mw 40,000 daltons. Nineteen patients completed therapy and have received adequate followup.
Commonly reported side effects of interferon alfa2b include. Jun 05, 2018 interferon treatment for hepatitis c would typically last 2448 weeks 612 months. To determine the efficacy of pegylated interferon alfa2a in the treatment of refractory inflammatory cystoid macular edema cmemethods. Pegasys, peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol. The burden of cystoid macular edema among those with uveitis is considerable. To report the effect of subtenon injections of natural leukocyte interferon. Interferon alfa 2a, interferon alfa 2b, peginterferon beta1a, and interferon beta1b may increase blood levels of zidovudine azt, retrovir. Oct 28, 20 to report the effect of subtenon injections of natural leukocyte interferon. Interferon alfa2b is indicated for the treatment of hairy. An update on the treatment of hemangiomas in children with.
It is not known whether interferon alfa 2a passes into breast milk. Treatment with pegylated interferon alfa2a led to an improvement in cme in all eyes of seven included patients, with a mean decrease. Based on its antiinflammatory, antiproliferative, and antiangiogenic effects, systemic and subtenon interferon alpha has been employed in the treatment of a wide range of posterior segment problems. The peripheral neuropathy and vision of the right eye improved, but the vision of the left eye worsened after stopping interferon. Successful treatment of chronic pseudophakic macular edema. Aug 27, 2011 well the interferon injection is given by subcutaneous mode, but the problem was that we were not getting the marks by which we can give see the markings and give the injection. Subtenon injection of natural leukocyte interferon. The peg moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to. In study 5 n630, subjects received either roferona interferon alfa 2a 3 miu three times a week, pegasys 5 mcg once weekly or pegasys 180 mcg once weekly. Nov 09, 2018 interferon alfa 2b can harm an unborn baby or cause a miscarriage. Indicated for metastatic renal cell carcinoma in combination with interferon alfa2a. Bevacizumab for nonocular indications medical clinical. Several fdaapproved drug labels may be available for peginterferon alfa2b. Nineteen patiens 20 eyes with the exudative form of macular degeneration were treated with parenteral interferon alfa 2a.
Evaluation of serum interferons in patients with agerelated macular. Interferon alpha 2b in the treatment of uveitic cystoid macular edema article in ocular immunology and inflammation 202. Injections, subcutaneous subject areas on research. To perform a prospective pilot study to evaluate interferon alfa 2a ifn alfa 2a for the treatment of refractory cystoid macular edema cme in endogenous uveitis. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances. Interferons medical clinical policy bulletins aetna. Fifteen patients 16 eyes had adequate followup for evaluation of outcome of the exudative macular lesion.
May 30, 2018 interferon alfa 2b is made from human proteins. Interferons in ophthalmology current status and advancing. A computergenerated, random numbers list was used for allocation of treatment groups. Roferona interferon alfa 2a, recombinant is a sterile protein product for use by injection. The dose of interferon alfa2a actually given was 76 to 100 percent of that scheduled for 53 percent of the patients, 50 to 75 percent of that scheduled for 29 percent, and less than 50 percent of. Interferon alfa2a has been shown to be effective as an antiangiogenic agent for several systemic human angiogenic disorders and has shown antiangiogenic activity in the laboratory. Interferon alpha is used for treating peyronies patients because it reduces the production of collagen in the plaque. Interferon, a natural multifunctional protein, has been an important part of medical therapy in various ophthalmic indications. A 66yearold man affected by dme, with glycated hemoglobin hba1c at 6. While this reaction may improve zidovudines effectiveness, it also may increase the risk of blood and liver toxicity. The aim of this study is to compare the effectiveness of bevacizumab. To assess the efficacy of interferon ifn alpha2a in the treatment of postuveitic refractory macular edema me. Safety and tolerability of pegylated interferon pegifn.
Recent progress in the treatment of uveitic macular edema. Pegylated interferon alphaassociated optic neuropathy. Peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy polyethylene glycol peg chain. Roferona is manufactured by recombinant dna technology that employs a genetically engineered escherichia coli bacterium containing dna that codes for the human protein. Interferon alfa2a, recombinant injection drug information. It has been used in the treatment of hepatitis, solid tumors and hematologic malignancies. Pegylated interferon alfa2a is an alfa interferon that is fda approved for the treatment of chronic hepatitis c and chronic hepatitis b. Interferon alfa 2b injection is used to treat hepatitis b and c, lymphoma lymph node cancer, malignant melanoma skin cancer, genital warts, hairy cell leukemia blood cell cancer, and kaposi sarcoma aidsrelated tumor. Interferon alpha injections have been used to treat peyronies patients. Some claims have been made that interferons produce about an 1838% reduction in the rate of ms relapses. Since 1993, ocular complications following interferon therapy have been reported mainly. Interferon alpha2a for subfoveal neovascularization in age. Objective to report the benefits and complications of subcutaneous interferon alfa2a therapy for hemangiomas in children design prospective nonrandomized trial setting tertiary care.
Interferon alfa 2a provides no benefit as a treatment for choroidal neovascularization secondary to agerelated macular degeneration and may be associated with a poorer visual outcome when given at a dose of 6 miu. Interferons are proteins released in the body in response to viral infections. Interferons caused many longterm side effects partly because of this long treatment time. Common questions and answers about interferon alfa 2b intron a. In some cases, health care professionals may use the trade names intron a, roferona or other names such as ifnalpha and alpha interferon when referring to the generic drug name interferon alfa.
Interferon alfa2a in the treatment of exudative agerelated. Interferon alfa2b injection route side effects mayo clinic. Interferons are important for fighting viruses in the body, for regulating reproduction of cells, and for regulating the immune system. Roferona is manufactured by recombinant dna technology that employs a genetically engineered escherichia coli.
Here a pilot study is reported in which 10 patients with exudative agerelated macular degeneration armd have been treated with a course of interferon injections. Interferon alfa2b injection route description and brand. In studies submitted to the fda, 868 hcvhiv coinfected patients were randomized to receive peginterferon alfa2a plus placebo, peginterferon alfa2a plus ribavirin, or interferon alfa2a plus. Interferon alfa2b for intramuscular, subcutaneous, intralesional, or intravenous injection intron a is a purified sterile recombinant interferon product. Interferon alfa2a should be discontinued if patient develops persistent or unexplained pulmonary infiltrates or pulmonary function impairment. Here a pilot study is reported in which 10 patients with exudative age. Interferon alpha2a for subfoveal n eovascularization in agerelated macular degeneration lon s. There has been recent interest in the use of systemic interferon alfa 2a treatment for choroidal neovascular membranes cnv. Local injections of interferon are used to treat condylomata acuminata. They found no evidence of improved visual acuity with potential harm. Peg interferon alfa2a is compared in a number studies. This means that it is not known whether interferon alfa 2a will be harmful to an unborn baby.
Corneal neovascularization cnv is a visionthreatening condition arising from various corneal diseases. Sep 10, 2011 interferon injections resolved tumors in patients with primary or recurrent ocular surface squamous neoplasia, with only one relapse reported among 15 eyes after extended followup, according to a. Interferon alfa2b is an immunological agent that is fda approved for the treatment of patients 18 years of age or older with hairy cell leukemia and indicated as adjuvant to surgical treatment in. Interferon beta1a also interferon beta 1alpha is a cytokine in the interferon family used to treat multiple sclerosis ms. Interferon alfa2a solution, reconstituted recon soln warnings. Interferon alfa is one antiangiogenic agent thought to function by inhibiting the migration and proliferation of vascular endothelial cells. Interferon alfa2a is ineffective for patients with choroidal neovascularization secondary to agerelated macular degeneration. Pharmacological therapy for macular degeneration study group. Ifn alfa2a was administered at an initial dose of 3 or 6 million iu depending on body weight per day subcutaneously. Diagram showing the study design for interferon versus methotrexate in intermediate uveitis with macular edema. Therefore, the dose of zidovudine may need to be reduced by as much as 75%. How does interferon alpha peyronies treatment work. After that, you can inject interferon alfa 2b yourself or have a friend or relative give you the injections. Pegasys, peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy.
Although not all of these side effects may occur, if they do occur they may need medical attention. Method of treatment of macular degeneration oculex. Roferona interferon alfa 2a, recombinant is manufactured by recombinant dna technology that employs a genetically engineered escherichia coli bacterium containing dna that codes for the human protein. Interferons are classified as alpha, beta and gamma interferons based on molecular structure and grouped into types 1 and 2 depending on their cellular effects.
The current study is a prospective randomized clinical trial to determine the effect of interferon alpha2a on eyes with subfoveal subretinal neovascularization secondary to agerelated macular. Well known trade names include intron a interferon alfa2b and roferona interferon alfa2a. A report of three cases to describe treatment of chronic irvinegass. Interferon alfa for the treatment of neovascular age. However, the absence of a clear doseresponse relationship raises the possibility that the observed differences result. Interferon injections may resolve ocular surface squamous. The specific activity of interferon alfa2b, recombinant is approximately 2. Interferon alfa2a, recombinant roferona is a sterile protein product for use by injection. Intron a interferon alfa2b injection, solution dailymed.
Sep 25, 20 interferon, a natural multifunctional protein, has been an important part of medical therapy in various ophthalmic indications. This medication can rarely cause or worsen serious rarely fatal medical conditions, including mentalmood conditions e. Find patient medical information for interferon alfa2a injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. B retinal vascular occlusion before interferon alfa2a treatment, at the 8month followup. Interferons help your bodys immune system respond to bacteria, viruses, cancer, or other invading substances interferon alfa 2b is used to treat hairy cell leukemia, malignant melanoma, follicular lymphoma, kaposis sarcoma caused by aids, and certain types of genital warts. Roferona interferon alfa2a, recombinant is indicated for the treatment of chronic hepatitis c and hairy cell leukemia in patients 18 years of age or older. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. The fermentation is carried out in a defined nutrient medium containing the antibiotic tetracycline hydrochloride at a concentration of 5 to 10 mgl. Comparison of the effects of subconjunctival injections of. Interferon alpha is the generic name for the trade name drugs intron a, roferona. Interferon has many side effects which often limit the dose and duration of therapy. Intraocular administration obviates the side effects associated. The peg moiety is linked at a single site to the interferon alfa moiety via a stable amide bond to lysine.
Interferon alfa 2a is in the fda pregnancy category c. Peginterferon alfa2a, is a covalent conjugate of recombinant alfa2a interferon approximate molecular weight mw 20,000 daltons with a single branched bismonomethoxy. Based on its antiinflammatory, antiproliferative, and antiangiogenic effects, systemic and subtenon interferon alpha has been employed in the treatment of a wide range of posterior segment problems with an inflammatory component such as. Interventions each patient received daily subcutaneous injections of interferon alfa 2a to a target dose of 3 million um 2 of body surface area for a minimum of 4 months. The efficacy of interferon alfa2a was studied in patients with sight threatening posterior uveitis or retinal vasculitis. Interferons are classified as alpha, beta and gamma interferons.
Topical interferon alpha 2b in the treatment of refractory. Ibm micromedex along with its needed effects, a medicine may cause some unwanted effects. Roferona interferon alfa2a, recombinant is a sterile protein product for use by injection. Interferons in ophthalmology current status and advancing trends. To perform a prospective pilot study to evaluate interferon alfa2a ifn alfa2a for the treatment of refractory cystoid macular edema cme in endogenous uveitis. It is produced by mammalian cells, while interferon beta1b is produced in modified e. Interferon alfa for the treatment of neovascular agerelated. Color photographs and fluorescein angiograms were evaluated independently by two masked readers for change. Patients were randomized into either a therapy with interferon beta 44. Clinical experience with interferon alfa2a for exudative.
Food and drug administration fda for the treatment of chronic hepatitis b virus infection and chronic hepatitis c virus infection. Do not use interferon alfa 2b with ribavirin rebetol if you are pregnant. Typical ocular lesions include cotton wool spots and retinal haemorrhages at the posterior. The combination of these medicines can cause birth. All patients were treated with subcutaneous injections of 6 million international units of interferon alpha2a, 3 times a week, for an average period of 10 months. Interferon versus methotrexate in intermediate uveitis. In study 6 n526, subjects received either roferona 6 miu three times a week for 12 weeks followed by 3 miu three times a week for 36 weeks or pegasys 180 mcg once weekly. Interferon alfa2a is ineffective for patients with. Treatment of refractory cystoid macular edema with pegylated.
There is a black box warning for this drug as shown. Clinical sciences longterm efficacy and safety of low. Interferon alfa2a, recombinant is a highly purified protein containing 165 amino acids, and it has an approximate molecular weight. Interferon alpha 2b in the treatment of uveitic cystoid.
To report the efficacy and safety of interferon alpha 2b in the treatment of pseudophakic cystoid macular edema resistant to conventional therapy. The average followup was 8 months range 511 months. Intron a interferon alfa2b uses, side effects, dosage. May 17, 2004 the wet form of agerelated macular degeneration amd affects approximately 250,000 americans per year. There has been recent interest in the use of systemic interferon alfa2a treatment for choroidal neovascular membranes cnv. Interferon alpha2a for proliferative diabetic retinopathy.
Intron a 5ml diluent interferon alfa2b, recombinant. Aidsinfo provides the following drug label solely as an example of the labels available for peginterferon alfa2b. Safety and tolerability of pegylated interferon peg ifn alfa2a in hiv infected people the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Aetna considers bevacizumab avastin, bevacizumab awwb mvasi, and bevacizumabbvzr zirabev exp erimental and investigational for the treatment of the following nonocular indications not an all. Interferons are substances produced by cells in the body to help fight infections and tumors. Antiangiogenic therapy is a new approach to the treatment of neovascular agerelated macular degeneration. Interferon alfa2a is ineffective for patients with choroidal neovascularization secondary to agerelated macular. Interferon associated retinopathy british journal of ophthalmology. Interferon alfa2b side effects, dosage, interactions. Interferon alfa2a is ineffective for patients with choroidal.
Patients were assigned interferon alfa2b, colchicine, and benzathine penicillin, or colchicine and benzathine. Clinical experience with interferon alfa2a for exudative age. Before you use interferon alfa 2b for the first time, you or the person who will be giving the injections should read the manufacturers information for the patient that comes with it. Human recombinant interferon alfa2a for the treatment of behcets. Interferon alpha2a treatment for postuveitic refractory macular. Interferon alfa2a for the treatment of chronic refractory cystoid.
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